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The Binding of Isaac | Episode 78 | Popular Synergies: Activate on Damage

134 views · Published 24 October 2014 · 28:16 · Indexed 17 October 2026

Channel: uidsea · 2014 · Gaming

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Today we're looking at all the items that activate on damage. 

Bowl of Tears
The Virus
Infestation
The Black Bean
Dead Bird

This makes for a weird pseudo-tanky run.

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The Binding of Isaac is about a young boy who gets thrown into the basement of his house by his fanatical mother, thinking she is doing the work of God. The premise is to complete each floor of his basement and descend down to the next floor dealing with increasingly difficult rooms and enemies, all while getting various items used to help or hinder your play through the game.

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