Polyarteritis nodosa (PAN) - Usmle step 1 pathology Case based discussion

4,496 views 路 Published 5 April 2017 路 9:23 路 Indexed 2 October 2026

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Polyarteritis nodosa (PAN) is a type of vasculitis that mainly affects medium-sized arteries.  Vasculitis includes a group of diseases where your immune system attacks the blood vessels and results in inflammation.  Inflammation of the arteries can lead to narrowing or blockage of blood vessels, causing a lack of blood supply to affected body tissues.  However, inflammation can also result in thinning of the blood vessel walls and aneurysm formation (dilation of the blood vessel) which can sometimes rupture.  In some cases, PAN can be caused by chronic hepatitis B virus infection.  In most cases, no cause is found (idiopathic).  PAN most commonly affects the skin, nerves, gut or kidney arteries.  Some forms of PAN affect only the skin (cutaneous PAN) or one body organ (localized PAN), while in other cases, the disease affects multiple organ systems (systemic PAN).

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