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Archive: Storage Lesions in Cellular Blood Components - James AuBuchon, MD

596 views · Published 15 July 2014 · 54:35 · Indexed 25 October 2026

Channel: UW Video · 2014 · Education

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While we often talk about getting better with age, this generally applies only to fine red wines. Even then, there's a limit to improvement before deterioration wins out. But what about blood? In this video from the University of Washington's Laboratory Medicine Grand Rounds series, Dr. James AuBuchon, president and CEO of the Puget Sound Blood Center explains how biochemical changes in platelets and red cells with ex vivo storage are many and varied, including surface changes as well as reductions in functional capabilities. The extent to which these changes reduce the effectiveness of transfusions, or possibly even harm transfusion recipients, remains unclear. Retrospective clinical studies have certainly raised concerns about "old blood," but prospective trials have failed to corroborate the incrimination. So what's best for the patient?

 James AuBuchon, MD
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