Interaction of the antagonist BX-471
184 views · Published 17 October 2012 · 0:27 · Indexed 26 September 2026
Channel: Imperial College London · 2012 · Science & Technology
Interaction of the antagonist BX-471 (magenta) which was found to interact with Tyr-113 and Tyr-114 (helix 3) and Ile-259 (helix 6), of the chemokine receptor CCR1 (residues shown as sticks). BX-471 is thought to lock CCR1 in an inactive conformation which cannot signal (5). For more information please visit http://www1.imperial.ac.uk/nhli/respiratory/leukocyte/chemo
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