Case studies using WGS to investigate TB cluster alerts in California

2,237 views · Published 9 November 2018 · 19:20 · Indexed 26 September 2026

Channel: Centers for Disease Control and Prevention (CDC) · 2018 · News & Politics

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In 2018, CDC's Division of TB Elimination (DTBE) began universal whole-genome sequencing (WGS) (i.e., sequencing an M. tuberculosis isolate for each U.S. case of culture-confirmed TB). Increasingly, state and local programs are using results of WGS and phylogenetic analyses to help guide TB cluster and outbreak investigations.  A training module on "Whole-genome sequencing for investigation of recent TB transmission in the United States: Current uses and future plans" is available here.

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