TBS #24 Bad Genes that Impact Thyroid Function

1,214 views · Published 23 August 2018 · 9:39 · Indexed 20 September 2026

Channel: Dr. Westin Childs · 2018 · People & Blogs

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A list of genes that impact thyroid function. 

Today is episode #24 and it's all about bad genes and how they impact your thyroid function. 

There are certain genetic changes, known as single nucleotide polymorphisms or SNP's for short, which can slightly impact certain enzymes in your body. 

These genes are very important when it comes to your thyroid because they can impact a set of enzymes known as the deiodinases. 

These deiodinases are responsible for activating or inactivating thyroid hormone at the cellular level. And they can be impacted by factors such as your genes, medical conditions, medications, and so on. 

There are 3 major deiodinase enzymes:

- D1 - You can consider this an activating enzyme and it is responsible for 30% of T3 in the body. 
- D2 - You can consider this an activating enzyme and it is responsible for 70% of T3 in the body. 
- D3 - You can consider this an inactivating enzyme which takes T4 and turns it into reverse T3 or rT3. 

Certain SNP's impact the function of these enzymes which create conditions in which you may not be able to convert T4 to T3 very well. 

DIO2 SNP's and DIO2 SNP's can both impact how your body tolerates certain medications. 

You can test for the presence of these enzymes which can help guide your treatment and help you understand which thyroid medication you should be on. 

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Disclaimer:
Dr. Westin Childs received his Doctor of Osteopathic Medicine from Rocky Vista University College of Osteopathic medicine in 2013.  His use of “doctor” or “Dr.” in relation to himself solely refers to that degree.  Dr. Childs is no longer practicing medicine and does not hold an active medical license so he can focus on helping people through videos, blog posts, research, and supplement formulation. To read more about why he is no longer licensed please see this page: https://www.restartmed.com/what-happened-to-my-medical-license/

This video is for general informational, educational, and entertainment purposes only.  It should not be used to self-diagnose and it is not a substitute for a medical exam, treatment, diagnosis, prescription, or recommendation.  It does not create a doctor-patient relationship between Dr. Childs and you.  You should not make any changes to your medications or health regimens without first consulting a physician.  If you have any questions please consult with your current primary care provider. Restart Medical LLC and Dr. Westin Childs are not liable or responsible for any advice, course of treatment, diagnosis, or any other information, services, or product you obtain through this website or video. 
#thyroid #hypothyroidism #hashimoto's