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F2 Isoprostane - the "lifestyle lie detector"; blood test to measure lifestyle - diet and exercise

861 views · Published 13 May 2017 · 7:59 · Indexed 30 September 2026

Channel: Dr. Ford Brewer MD MPH · 2017 · Science & Technology

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ABOUT DR. BREWER
Dr. Brewer started as an Emergency Doctor.  After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine.  While there, he went on the run the post-graduate training program (residency) in Preventive Medicine.  From there, he made a career of practicing and managing preventive medicine and primary care clinics.  His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics.  He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline.  We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event.  Dr. Brewer provides services via telemedicine or in person if you're in the Lexington, KY area.  We find a lot of undiagnosed Pre-Diabetes or Insulin Resistance.  Treating unrecognized risk factors like Pre-Diabetes allows reduction of risk and prevention of disease.

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ABOUT THIS VIDEO:
F2 isoprostane is a marker for increased oxidation in the artery wall. It is a marker for oxidation due to lifestyle issues, such as poor diet and exercise. Is is the final component of the cardiovascular inflammation panel.  What is it? 
If you go to Wikipedia, you'll see it's a prostaglandin. These are hormone-like molecules that are made from fat molecules (fatty acids). Prostaglandins, prostacyclines and thromboxane are all made from arachadonic acid. We discussed arachadonic acid and thromboxane in another video. Thrombaxane is used in the urine as a marker for aspirin function - the Aspirin Works test. 
F2 - Isoprostane is used as a marker for oxidation - or inflammation in the arteries, which leads to heart attack and stroke. Oxidation makes an apple brown, and leads to aging and inflammatory diseases such as diabetes, heart disease and stoke, and rheumatoid arthritis.

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