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Archive: Target Sequencing of Cancer Samples

863 views · Published 12 May 2014 · 59:06 · Indexed 8 November 2026

Channel: UW Video · 2014 · Education

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Targeted Sequencing of Cancer Samples for Clinical Testing and Functional Analysis of Tumor Subclones

Dr. David Spencer discusses the performance of various targeted next-generation sequencing methods for detecting cancer-associated mutations in clinical samples. In this presentation, Targeting Sequencing of Cancer Samples for Clinical Testing and Functional Analysis of Tumor Subclones, Dr. Spencer demonstrates that cross-contamination of samples can occur during the course of multiplex sequencing and presents preliminary data on methods for detecting such admixture from sequencing data. His presentation also illustrates the use of targeted next-generation sequencing to study the functional properties of subclonal populations of cells in primary acute myeloid leukemia samples and Merkel cell carcinoma, an aggressive skin cancer that is typically driven by a common polyomavirus. 

David Spencer, MD, PhD
Fellow, Division of Molecular Genetic Pathology
Department of Laboratory and Genomic Medicine
Washington University School of Medicine, St. Louis

4/30/2014
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