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Spatial and Temporal Structure in the GI Microbiota

1,707 views · Published 10 October 2017 · 1:55 · Indexed 6 November 2026

Channel: ASM - Microbes Make Our World · 2017 · Science & Technology

The human gut microbiome is the subject of intense study due to its importance in health and disease. The majority of these studies have been based on the analysis of feces. However, little is known about how the microbial composition in fecal samples relates to the spatial distribution of microbial taxa along the gastrointestinal tract. By characterizing the microbial content both in intestinal tissue samples and in fecal samples obtained daily, we provide a conceptual framework for how the spatial structure relates to biotic interactions on the community level. We further describe general categories of spatial distribution patterns and identify taxa conforming to these categories. To our knowledge, this is the first study combining spatial and temporal analyses of the human gut microbiome. This type of analysis can be used for identifying candidate probiotics and designing strategies for clinical intervention.

Title: Linking Spatial Structure and Community-Level Biotic Interactions through Cooccurrence and Time Series Modeling of the Human Intestinal Microbiota

Authors: Eric J. de Muinck, Knut E. A. Lundin, Pål Trosvik

Editor: Morgan G. I. Langille

DOI: https://doi.org/10.1128/mSystems.00086-17

Published in mSystems® on 5 September 2017

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