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Fighting Obesity at the cellular level by shutting off Hunger

122 views · Published 24 April 2018 · 1:22 · Indexed 22 October 2026

Channel: Rajamanickam Antonimuthu · 2018 · Science & Technology

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An international team uncovered the potential to beat obesity at the cellular level with a receptor that shuts off hunger. 

The team determined the first crystal structure for a neuropeptide Y receptor, deciphering the thousands of carbon, oxygen, nitrogen and other atoms involved with it and how they bind to one another.

This is a very important milestone in the drug discovery process.

The findings may open up opportunities to fight obesity at the cellular level.

Pharmaceutical companies long have attempted to develop a small-molecule drug that could do just that. But until now, nobody knew exactly what the receptor looked like, making it nearly impossible to design the key to activating it.

It was like trying to design a key without knowing the shape of the keyhole.

Characterizing ‘keyhole’ is first step to fighting obesity at the cellular level
 
The next step in this molecular-level research is target validation: proving that the receptor really does control hunger. Past studies revealed that when the receptor is blocked from functioning in mice, they become obese.

Image: Brian Bender/Vanderbilt University

Video Source: Vanderbilt University

News Source:  https://news.vanderbilt.edu/2018/04/18/characterizing-keyhole-is-first-step-to-fighting-obesity-at-the-cellular-level/

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