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Archive: Significance of Minimal Residual Disease in Acute Myeloid Leukemia

2,907 views · Published 19 February 2014 · 58:32 · Indexed 8 October 2026

Channel: UW Video · 2014 · Education

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Most patients with acute myeloid leukemia (AML) ultimately experience disease recurrence even after achievement of a morphologic complete remission, demonstrating the inability of traditional microscopy-based assessments of AML burden. Over the last decade or so, several methods have been developed that enable the detection of submicroscopic, "minimal" residual disease (MRD) in AML patients. In this presentation, I will discuss these techniques and review the increasing body of evidence indicating that the presence of MRD identifies a subset of patients at high risk of disease relapse during and after conventional chemotherapy as well as hematopoietic cell transplantation. I will also summarize the attempts that were made so far to use MRD as marker for therapeutic decision-making and highlight the need for better controlled studies before such strategies should be considered standard of care.

Roland Walter, MD, PhD, MS

1/29/2014
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