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Modeling circadian clocks : From molecular... (Remote Talk - Lecture 1) by Albert Goldbeter

429 views · Published 19 September 2018 · 1:26:58 · Indexed 29 September 2026

Channel: International Centre for Theoretical Sciences · 2018 · Science & Technology

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ORGANIZERS : Vidyanand Nanjundiah and Olivier Rivoire

DATE & TIME  : 16 April 2018 to 26 April 2018

VENUE : Ramanujan Lecture Hall, ICTS Bangalore

This program is aimed at Master's- and PhD-level students who wish to be exposed to interesting problems in biology that lie at the biology-physics interface. Besides familiarity with basic biology, they will be expected to have an adequate background in physics and/or mathematics. The school will consist of formal lectures as well as informal tutorial sessions.

Two themes form the background to the school. First, evolution by natural selection, while being the chief mode of adaptive evolution, is subject to significant constraints, for example, because of intra-molecular correlations between amino acids in proteins or physical forces in multicellular development. Second, some long-term evolutionary outcomes resemble the short-term behaviour of physico-chemical matter that is based on generic, which is to say mechanical and chemical, properties of solids and liquids.

The topics to be covered in the lectures are based on these themes and can be outlined in terms of four questions.

(a) Do physical constraints impede or favour the adaptation of evolving systems?
(b) To what extent can evolutionary outcomes be explained in terms of the short-term behaviour of physical systems?
(c) How may mathematical models help in understanding fundamental principles of spatio-temporal organisation in living systems?
(d) Can quantitative experiments and large-scale data provide new conceptual insights on living matter?

These questions will be illustrated in a range of contexts from molecular evolution to ecology through cell and tissue dynamics.

 
PROGRAM LINK
https://www.icts.res.in/program/LivingMatter2018

Table of Contents (powered by https://videoken.com)
0:00:00 Start 
0:00:10 Modeling circadian clocks: From molecular mechanism to physiological disorders (Remote Talk) Lecture 1
0:01:58 Main biological rhythms Biochemical
0:13:24 Some recently discovered cellular rhythms
0:16:17 A synthetic oscillatory network of transcriptional regulators
0:18:09 FEBS Lett. 2012
0:18:54 Circadian rhythms allow adaptation to the environment
0:20:34 Circadian rhythms (T = 24 h)
0:21:39 1960s: Circadian rhythms
0:22:02 Jean-Jacques d' Ortous de Miran
0:24:00 Circadian rhythm of locomotor activity in flying squirrel
0:27:21 Circadian rhythms: Physical versus molecular models
0:28:06 The van der Pol oscillator
0:29:01 Van der Pol oscillator model for circadian rhythms
0:30:22 Molecular models for circadian rhythms
0:32:41 Seymour Benzer (1921-2007)
0:36:48 Perte de compensation de temperature des rythmes circadiens chez les mutants Per' et Pers
0:38:39 1984 Hall and Rosbash --- Young
0:40:22 PNAS (1984)
0:40:25 1990: Hardin, Hall et Rosbash
0:41:19 Nature (1990)
0:41:39 Negative feedback of PER on per expression
0:45:10 Oscillatory Behavior in Enzymatic Control Processes
0:47:52 Model #1 : Negative autoregulation of the Per gene by PER
0:49:49 Kinetic equations for the model for PER circadian oscillations
0:55:13 Circadian rhythms in cyanobacteria:
0:55:49 Cyanobacteria
0:55:51 Science (2005)
0:56:16 1994 Discovery of a second clock gene in Drosophila
0:56:37 Loss of Circadian Behavioral Rhythms and per RNA Oscillations in the Drosophila Mutant timeless
0:56:46 Block in Nuclear Localization of period Protein by a Second Clock Mutation, timeless
0:57:10 Role of TIM in the control of
0:58:51 Model #2 : Incorporating the role of TIM and the effect of light
1:00:55 Circadian oscillations in DD, LD and LL
1:02:15 Phase shift by a light pulse
1:03:52 Phase response curve for Drosophila: Comparison of theoretical predictions with experiments
1:04:02 Autonomous chaos
1:04:44 Nonautonomous chaos: Effect of waveform of LD cycle
1:05:02 Long-term suppression
1:07:19 Modeling circadian oscillations with interlocking positive
1:07:30 Effect of molecular noise
1:08:22 Robustness of circadian rhythms with respect to molecular noise
1:08:35 Noisy limit cycle
1:09:20 Circadian rhythms in mammals:
1:09:39 Suprachiasmatic nuclei and the mammalian circadian clock
1:10:14 Synchronization of circadian rhythms in the
1:10:54 Interacting molecular loops in the mammalian circadian clock.
1:11:40 The mammalian circadian network
1:12:10 Model #3 : Model for the mammalian circadian clock
1:12:49 Model for the mammalian circadian clock
1:14:40 Model for the mammalian circadian clock: Multiple sources of oscillations
1:15:11 Link with physiological disorders of the human sleep-wake cycle
1:16:10 Sleep pattern in adolescents
1:20:09 Sometimes, entrainment fails to occur...
1:20:23 Absence of entrainment of circadian rhythms
1:21:59 Influence of circadian rhythms on the timing of medications
1:22:04 Conclusions
1:25:01 Q&A

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