Integrating Computation and Experiment in Functional Deimmunization of Therapeutic Proteins

347 views · Published 27 September 2010 · 2:33 · Indexed 10 October 2026

Channel: Dartmouth · 2010 · Education

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Assoc. Professor Chris Bailey-Kellogg, Computer Science, and  Asst. Professor of Engineering Karl Griswold,  discuss their efforts to develop  an integrated suite of general methods combining computation and experiment in order to produce immunotolerant variants of therapeutic proteins, in which immunogenicity is reduced while therapeutic activity is maintained.

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