Laxative Use & The Gut: Lasting Changes Observed in Mice

4,219 views · Published 29 August 2018 · 3:17 · Indexed 25 September 2026

Channel: DavidPerlmutterMD · 2018 · Science & Technology

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These days, it seems like more and more Americans are taking laxatives to combat constipation. Osmotic laxatives, like Miralax and Lactulose, are one of the most popular OTC options for this. What these types of laxatives do is fill the digestive tract with particles, which attracts fluid inside the gut, flushing out the system and causing a bowel movement.

A new study looked to understand if these types of treatments are a free ride to improved digestion, or if the body was actually paying a price for these interventions in the digestive tract. Let's take a look at the results of this study, which was performed in mice.

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