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The Binding of Isaac | Episode 45 | Popular Synergies: Mom's Knife, Poly, Sacred Heart, Belial

237 views · Published 19 September 2014 · 40:11 · Indexed 4 November 2026

Channel: uidsea · 2014 · Gaming

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We're back with another popular synergy and this is the combination if you want ultra damage for the run. I one shot almost every enemy in the run, including bosses.

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The Binding of Isaac is about a young boy who gets thrown into the basement of his house by his fanatical mother, thinking she is doing the work of God. The premise is to complete each floor of his basement and descend down to the next floor dealing with increasingly difficult rooms and enemies, all while getting various items used to help or hinder your play through the game.

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