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CLEAR study-Mayo Clinic

1,079 views · Published 6 July 2010 · 1:20 · Indexed 20 September 2026

Channel: Mayo Clinic · 2010 · Science & Technology

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Dr. William D. Freeman, critical care neurologist at Mayo Clinic in Florida offers information about a new study for stroke patients. 

The CLEAR study is a study focused on treating a devastating stroke subtype known as intracerebral hemorrhage with intraventricular extension which is bleeding in the spinal cavities of the brain. This type of stroke occurs in about 8-10% of patients especially those who have hypertension or high blood pressure. The current management of these patients is placement of a drain within the brain that allows bypass of fluid into a bag. The mortality of this condition remains very high between 50-80% by one month. The purpose of this study is to investigate the injection of the clot busting drug that dissolves the clot within the brain quicker than simply having a drain in place alone. The study has had a phase 1 and a phase 2 trial that found the optimal timing and amount of drug to give which is 1 mg every 8 hours through the drain. The preliminary findings are very promising and show that the clot is dissolved faster than placebo/saline. Eligible patient's or those in which have a CT scan documenting the type of intracranial hemorrhage noted above and have to have relatively normal laboratory tests of bleeding function, as well as either the patient or her proxy available for consent. Mayo Clinic is one of the few sites in the region per dissipating in the study for this devastating type of brain hemorrhage. This cutting edge research study may become the future therapy for this condition if the results are confirmed positive. Patient's or emergency room doctors can call 904 286-0239 which is the cerebrovascular Mayo pager for possible eligible patients.

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