Simple Test Could Appropriately Reduce Use of Chemotherapy in Colon Cancer Patients-Mayo Clinic
1,779 views · Published 26 May 2010 · 4:34 · Indexed 15 October 2026
Channel: Mayo Clinic · 2010 · Science & Technology
Patients with stage II colon cancer who have a specific defect in the ability to repair their DNA do not benefit from a common type of chemotherapy, says a research team from Mayo Clinic. They do fine with just surgery. The scientists say their findings, to be presented at the June 4-8 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, suggest that stage II patients should have a simple, affordable test to check the status of their mismatch repair (MMR) proteins. Those patients with deficient MMR (dMMR) do not benefit from treatment with a common regimen of rapid infusion 5FU and leucovorin. The study is likely the most definitive to date on the connection between dMMR and treatment and outcome of stage II colon cancer, says the lead author, George P. Kim, M.D., an oncologist at the Mayo Clinic campus in Florida. Visit our newsblog to read more: http://newsblog.mayoclinic.org/2010/05/26/simple-test-could-appropriately-reduce-use-of-chemotherapy-in-colon-cancer-patients/
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