Look Who it Was Random video

Understanding CV Risk: Epigenetics - The Methylome - key to longevity?

4,459 views · Published 5 March 2018 · 13:23 · Indexed 28 September 2026

Channel: Dr. Ford Brewer MD MPH · 2018 · Science & Technology

Watch on YouTube

Want to learn one of the basics of heart attack & stroke prevention... for free? Get free access to the CV inflammation course by completing this form: https://care.prevmedhealth.com/FreeOnlineCourse.

Learn how to predict & prevent heart attack & stroke:  
https://care.prevmedhealth.com/How-To-Predict-a-Heart-Attack.

Learn how to reduce & reverse arterial plaque:  
https://care.prevmedhealth.com/How-To-Reverse-Arterial-Plaque. 
--

ABOUT THIS VIDEO:
The Human Genome Project .gov site shows the first description of the Human Methylome. What is a methylome? It is the epigenetic control of genes by methylation. 
Epigenetics is control of genetic expression through non-DNA methods. It actually controls access to the 3 billion base pair sequence. It's like controlling the spools on which a large wire is wound. Methylation is usually (but not always) on the CG base pairs. Methylation involves cell differentiation during the development of the embryo. So, again, controlling genetic expression through the epigenetic process METHYLATION could result in development of stem cells from differentiated cells. 
So, ways of longevity, like Valter Longo's Mimicked Fasting, Nir Barzilai's TAME study, and David Sinclair's NMN are all ways of jump-starting, or rekindling the expression of genes that were active when we had younger, more active metabolism. Examples including MTOR, AMPK, SIRT-1.
So, again, theoretically, if we can control methylation, we can control aging. (I don't, however, think that will happen any time soon.)

Join the PrevMed Community: https://mailchi.mp/1224fb9e00e7/prevmed_community

For information regarding our services or to become a patient visit: https://prevmedheartrisk.com/

ABOUT DR. BREWER
Dr. Brewer started as an Emergency Doctor.  After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine.  While there, he went on the run the post-graduate training program (residency) in Preventive Medicine.  From there, he made a career of practicing and managing preventive medicine and primary care clinics.  His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics.  He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline.  We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event.  Dr. Brewer provides services via telemedicine or in person if you're in the Lexington, KY area.  We find a lot of undiagnosed Pre-Diabetes or Insulin Resistance.  Treating unrecognized risk factors like Pre-Diabetes allows reduction of risk and prevention of disease.

If you are interested in becoming a patient, please visit our website: https://prevmedheartrisk.com/

More from this channel