X-chromosome linked genetic disorders
241 views · Published 17 July 2014 · 10:44 · Indexed 22 October 2026
Channel: Nikolay's Genetics Lessons · 2014 · Education
X-linked refers to genes that are on the X chromosome. So the X chromosome is one of the two sex chromosomes that we have in humans. Females have two X chromosomes, and males have an X and a Y chromosome. Most genes on the X chromosome, when mutated, only show a phenotype in males. And that's because, since females have two X chromosomes, the chromosome that doesn't have a mutation can often compensate for the other X chromosome if it has a mutation. Some X-linked conditions that individuals may be familiar with are Fragile X syndrome, hemophilia A, and Duchenne muscular dystrophy. But there are some conditions that are more common in females, such as Rett syndrome, which is also due to mutation on the X chromosome.
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