Selection against homozygous recessive genotype
3,268 views · Published 16 June 2014 · 17:11 · Indexed 12 November 2026
Channel: Nikolay's Genetics Lessons · 2014 · Education
Why Harmful Alleles Persist In the last tutorial, we saw how natural selection, by acting on favorable or unfavorable phenotypes, can shift allele frequencies in populations. It’s reasonable to think that because they produce phenotypes that make individuals less fit, harmful alleles should disappear from any gene pool. But that tends not to be the case. Because harmful alleles are often recessive alleles, they can persist in a population almost indefinitely. And, even harmful dominant alleles, despite selection against the phenotypes they produce, can also often continue to persist in gene pools.
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