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Preview of The Neuroendocrine Basis of Adrenal Fatigue Syndrome

3,915 views · Published 6 February 2013 · 6:05 · Indexed 9 October 2026

Channel: Lam Clinic · 2013 · Education

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To truly celebrate the body's heroic effort to rescue us from stress, it's important to first understand that our brain is in control, the pathway is through the neuroendocrine system. 
 
  https://www.drlamcoaching.com/neuroendocrine-stress-adrenal-fatigue/ 
 
 - Stress enters our sphere through a small area of our brain called the Locus coeruleus or the LC. An important homeostatic control center of the body, the LC receives input from a variety of sources. From our senses, it's then routed through the hypothalamus, the amygdala, the cerebellum as well as the prefrontal cortex. Emotional pain and stressors from the outside world enters our inner world through these pathways. Once arrived, excitatory signals trigger production and releases norepinephrine from the LC. 
 
 - Norepinephrine has 2 functions: In the brain, it acts as a central neurotransmitter and keeps us aroused, we become alert. Norepinephrine, released from the LC also increases the sympathetic discharge and inhibits parasympathetic tone in the peripheral nervous system. At that point, it exerts its excitatory effect directly on the target organ such as the heart. So as a result, the heart rate as well as the heart beat force goes up.
 
 - The LC is also connected on the output side to many parts of the central nervous system including the spinal cord, brain stem, cerebellum, hypothalamus, amygdala as well as cerebral cortex. So as you can see, it's a two-way street with many, many directions and a collaborative network of information flow to the LC and out of LC. Collectively, the LC and the areas of the CNS, called the Central Nervous System, affected by the norepinephrine it produces, are described as the LC-NA System, stands for Local Coeruleus Noradrenergic System. Noradrenergic is the same as norepinephrine and that's what it connotates here. Now the distribution, as we talked about of the LC-NA System, is ubiquitous and is consistent with the prominent role that norepinephrine plays in a variety of CNS functions as well as behavior that includes local motor functions, cognitive functions, motivation, and attention. 
 
 - Once the LC-NA System is activated, it is responsible for much of the psychological effects we see in Adrenal Fatigue Syndrome. They can include fear, anxiety, alertness, memory changes, REM sleep dysregulation. Psychiatric research has documented that the role LC plays in cognitive function, in relation to stress, is complex and multi-model, there's no one direct link, multiple factors are involved. From a neuroendocrinological perspective, it is clear that the body's multiple stress response pathway are offered in a redundancy patent to handle stress in many, many cases. It has ensured the survival of our species for quite some time. 
 
 - What one person perceives as stress, may not be for another person. Based on what is perceived as stress by the mind, the body automatically activates any or all of the anti-stress mechanisms in place. In order for us to fully graph the big picture, clinicians need to take a step back. Because it is easy to be confused when you look too close. The picture from afar is quite clear. 
 
 - The more severe the stress, the more other systems, such as musculoskeletal, psychiatric, cardiac, and immune systems are also affected adversely. Remember that the body is a closed system. Severe dysregulation of one system invariably affects other systems. This is inescapable. Despite this clinical chaos, we can see a controlled collapse that is logical and systematic from the body's perspective. Symptoms are simply the messages or signs the body sends us warning of such impending danger, and thereby alerting us to take appropriate action. Now if stress are never really resolved or let go, then even despite a losing battle, the mind continues to be ultimately in charge throughout this ordeal, through its various neuroendocrinological stress response pathway. 

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Could you have Adrenal Fatigue? Learn the real signs and symptoms:

1. Educate yourself: Read our main article, ""Fundamentals of Adrenal Fatigue"":
  » https://www.drlamcoaching.com/adrenal-fatigue/concepts/fundamentals-adrenal-fatigue/

2. Take our 3-minute Test and learn if you could be experiencing Adrenal Fatigue:
  » https://www.drlamcoaching.com/adrenal-fatigue/adrenal-fatigue-test/

3. Have any questions? Ask Dr. Lam:
  » https://user.drlam.com/user/request-call-back-2.asp

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