Parsing out blood stem cells

1,873 views · Published 18 March 2010 · 5:47 · Indexed 29 September 2026

Channel: Cell Press · 2010 · Science & Technology

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For many years, researcher thought that blood stem cells (HSCs) were a fairly uniform population.  However, recent studies have started to show that this is not really true, and there are actually functionally distinct subpopulations within the overall HSC pool.  In this video, Grant Challen and Margaret Goodell take you on a brief tour of their latest Cell Stem Cell paper, in which they describe purifying and characterizing two subtypes of mouse HSC.  They show that the cells distinct properties are stable through repeated transplantations, and that they respond differently to signalling by the growth factor TGFb.

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