Learning-Related Plasticity in NDNF Layer 1 Interneurons

746 views · Published 7 November 2018 · 5:48 · Indexed 6 November 2026

Channel: Cell Press · 2018 · Science & Technology

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For more information, see Abs et al., Neuron 100/3, http://www.cell.com/neuron/fulltext/S0896-6273(18)30774-8.

How does the brain distinguish between relevant and irrelevant information? Layer 1 of neocortex plays a crucial role in this. In this video, Abs et al. identify NDNF as a specific marker for layer 1 interneurons and show that NDNF interneurons integrate top-down inputs and mediate a prolonged form of dendritic inhibition, which is highly experience dependent.

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