Fluoroquinolone resistance in bacteria

2,235 views · Published 27 June 2014 · 3:51 · Indexed 6 November 2026

Channel: Cell Press · 2014 · Science & Technology

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Liam Redgrave, Sam Sutton, Mark Webber, and Laura Piddock discuss bacterial resistance to fluoroquinolones. They explore how fluoroquinolones target bacterial type II topoisomerases to interfere with cell division and DNA replication, increases in fluoroquinolone resistance rates found in bacterial infections, global epidemic spread of fluoroquinolone resistant clones as fluoroquinolone resistance can give protection against other antibiotics, and the types of mutations that allow bacteria to become resistant to fluoroquinolones. More details can be found in the related Trends in Microbiology review article on "Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success" at http://www.cell.com/trends/microbiology/abstract/S0966-842X(14)00089-4. 

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