Disinhibition of Striatal Neurons Gates Cocaine Inhibition

1,130 views · Published 1 June 2016 · 4:47 · Indexed 12 November 2026

Channel: Cell Press · 2016 · Science & Technology

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For more information, see the paper by Dobbs et al., Neuron 90(5), http://www.cell.com/neuron/fulltext/S0896-6273(16)30118-0.

Dobbs and colleagues show that synchronized stimulation of axon collaterals from indirect-pathway striatal neurons can inhibit action potential firing in direct-pathway striatal neurons. Cocaine suppresses this inhibition via activation of D2 receptors in striatal neurons in order to promote locomotion.

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