Glycolysis Powers Synaptic Function during Energy Stress
595 views · Published 12 April 2016 · 3:01 · Indexed 8 November 2026
Channel: Cell Press · 2016 · Science & Technology
For more information, see the paper by Jang et al., Neuron 90(3), http://www.cell.com/neuron/fulltext/S0896-6273(16)00211-7. Changes in neuronal activity create local and transient changes in energy demands at synapses. Here, Jang and Nelson et al. discovered that glycolytic enzymes form microcompartments in vivo near synapses, or “glycolytic metabolons,” to meet local energy demands and support synaptic functions during conditions of acute energy stress (i.e., hypoxia and neuronal stimulations).
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