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Shuichi Takayama | Biomedical Micro- and Nanofluidics

4,312 views · Published 25 November 2015 · 46:42 · Indexed 27 October 2026

Channel: Michigan Engineering · 2015 · Science & Technology

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2015 LNF User Symposium

While the Lurie Nano-Fabrication Lab is a facility that largely supports electronics engineering and applications, the capabilities and services provides are critical for biomedical research as well. There is great need to improve the healthcare system through more efficient development of therapeutics and diagnostics. This presentation will provide an overview of efforts to apply micro- and nanofabrication capabilities to manipulation of cells, proteins, and DNA. The micro- and nanofluidic technologies to be discussed include computer-controlled microfluidics, self-switching microfluidic transistor circuitry, “reagent” microfluidics that utilize aqueous two-phase systems to enable microscale stable spatial fluidic patterning without any channels, and fracture fabrication of tunable nanochannels. Specific biomedical applications that will be discussed include organs-on-a-chip systems such as oviduct-on-a-chip for vitro fertilization and heartbeat-on-a-chip, chromatin analysis in fracture-fabricated nanochannels, and technologies to help develop protein diagnostics. The long-term goal is to create miniature patients-on-a-chip for understanding disease mechanisms, accelerating therapeutics and diagnostics development, enhancing cell-based therapies.

About the Professor:
Prof. Shuichi Takayama’s research interests (B.S. & M.S. from the University of Tokyo, Ph.D. from the Scripps Research Institute) started with organic synthesis. Subsequently he pursued postdoctoral studies in bioengineered microsystems at Harvard University as a Leukemia and Lymphoma Society Fellow. He is currently Professor at the University of Michigan in the Biomedical Engineering Department and Macromolecular Science and Engineering Program, and Adjunct Professor at the Ulsan National Institute of Science and Technology (UNIST) in Korea. He is an associate editor of Integrative Biology, and editorial board member of Scientific Reports. Research topics include microfluidic models of the body such as the oviduct, lung, gut, and cancer metastasis. He also develops aqueous two phase system micropatterning technologies, studies timing and rhythms of cell signaling, constructs self-switching fluidic circuits, and performs nanofluidic single strand chromatin analysis. Awards and honors include the NSF CAREER award, Pioneers of Miniaturization Prize from the Royal Society of Chemistry, and AIMBE Fellow. Disclosures: Co-founder & shareholder PHASIQ, Inc; Some stock options and licensed technology to 3D Biomatrix. 
http://www.bme.umich.edu/people/index.php?un=takayama

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