Chronic Stress and Decision-Making / Cell, November 16, 2017 (Vol. 171, Issue 5)
1,955 views · Published 16 November 2017 · 2:59 · Indexed 10 November 2026
Channel: Cell Press · 2017 · Science & Technology
How does chronic stress impact decision making? Ann Graybiel and colleagues demonstrate that chronic stress changes how rats weigh costs and benefits of decisions to seek higher rewards despite higher costs. These behavioral effects are mediated by prefronto-striatal circuit dynamics and can be blocked or mimicked by selective optogenetic manipulation. Check out the paper at: http://www.cell.com/cell/fulltext/S0092-8674(17)31239-4. Alexander Friedman, Daigo Homma, Bernard Bloem, Leif G. Gibb, Ken-ichi Amemori, Dan Hu, Sebastien Delcasso, Timothy F. Truong, Joyce Yang, Adam S. Hood, Katrina A. Mikofalvy, Dirk W. Beck, Norah Nguyen, Erik D. Nelson, Sebastian E. Toro Arana, Ruth H. Vorder Bruegge, Ki A. Goosens, and Ann M. Graybiel (2017). Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making. Cell 171. And read more great research at http://www.cell.com/cell/home.
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