Viscoplasticity Enables Mechanical Remodeling of Matrix by Cells
563 views · Published 15 November 2016 · 0:07 · Indexed 25 October 2026
Channel: Cell Press · 2016 · Science & Technology
Time-lapse video of a 3T3 fibroblast expressing RFP-Lifeact (red) in a collagen gel. Collagen fibers were taken by confocal reflectance microscopy and labeled as white. Note that collagen fibers are significantly aligned toward the cell when the cells exert forces to pull the collagen fibers. RFPactin and collagen fibers were captured at one frame/3 min using confocal microscopy. The video plays at 10 frames/s. In the manuscript, the authors characterize the degree of plasticity of collagen network deformations induced by cells. See the article by Nam et al. in the November 15 issue of Biophysical Journal (http://www.cell.com/biophysj/fulltext/S0006-3495(16)30887-6).
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