A Zebrafish Genetic Screen Identifies Nmu as a Sleep Regulator

1,630 views · Published 17 February 2016 · 7:03 · Indexed 19 October 2026

Channel: Cell Press · 2016 · Science & Technology

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For more details, see the paper by Chiu et al., Neuron 89(4), at http://www.cell.com/neuron/fulltext/S0896-6273(16)00008-8.

Chiu et al. perform a genetic screen in zebrafish and identify Nmu as a regulator of sleep/wake behaviors. They show that Nmu overexpression activates brainstem Crh neurons and that Nmu-induced arousal requires Crh signaling, thus identifying a novel vertebrate arousal circuit.

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