A Unique Ligand Limiting Neuronal Adaptations Necessary to Extinguish Fear

1,820 views · Published 11 July 2018 · 4:53 · Indexed 6 November 2026

Channel: Cell Press · 2018 · Science & Technology

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For more information, see Giza et al., Neuron 99/1, http://www.cell.com/neuron/fulltext/S0896-6273(18)30422-7.

Dr. Giza and co-authors reveal how they arrived at the discovery that the BDNF Met prodomain is the first ligand eliminating mature spines and synapses in hippocampal neurons. They also describe that the neurons developing in the presence of the Met prodomain are unable to grow the proper connections needed to adapt and eliminate unnecessary fears.

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