Jpx RNA Activates Xist by Evicting CTCF

3,459 views · Published 10 June 2013 · 6:47 · Indexed 25 October 2026

Channel: Cell Press · 2013 · Science & Technology

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Jeannie Lee and colleagues show that the X-linked Jpx noncoding RNA antagonizes the autosomally encoded CTCF transcription factor by titrating it away from the Xist promoter during X chromosome inactivation in mammals, delineating a new mechanism of epigenetic regulation by a noncoding RNA.

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