Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

2,845 views · Published 24 May 2013 · 5:01 · Indexed 21 September 2026

Channel: Cell Press · 2013 · Science & Technology

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Erika Pearce and colleagues challenge previous ideas about T cell metabolism by showing that activated T cells switch from oxidative phosphorylation to aerobic glycolysis not to promote proliferation but instead to augment the production of the antimicrobial protein IFN-γ, which is regulated by the glycolytic enzyme GAPDH.

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