T. gondii Requires the Twisting Motion Driven by the RON Protein Complex
1,857 views · Published 11 July 2018 · 0:26 · Indexed 26 October 2026
Channel: Cell Press · 2018 · Science & Technology
T. gondii requires the twisting motion driven by the RON protein complex to close the parasitophorous vacuole. During invasion, T. gondii hijacks a piece of the host cell membrane to form the parasitophorous vacuole (PV). This video shows the consequence when immobilization beads (blue) prevent the RhOptry Neck (RON) protein complex (red) from completing its mechanical twisting motion to trigger PV scission from the host membrane (green). Impeding the RON twisting motion prevents appropriate closure of the PV, which results in vacuole swelling and ultimately death of the parasite. For additional details, see Pavlou et al. (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30315-9).
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