Putting the 'Pop' into Apoptosis
4,427 views · Published 7 December 2018 · 0:42 · Indexed 3 October 2026
Channel: Cell Press · 2018 · Science & Technology
Bcl-2 proteins are key players in intrinsic apoptosis, the form of programmed cell death characterized by the permeabilization of the mitochondrial membrane. When cell death is triggered, the pro-apoptotic Bcl-2 protein Bax translocates from the cytosol to the outer mitochondrial membrane and oligomerizes, forming channels that release cytochrome c, which causes activation of the apoptosome. Here, David Andrews and colleagues show that Bax goes to mitochondria before organelles lose transmembrane potential. The HeLa cells express YFP-Bax (green), and mitochondria with normal transmembrane potential are stained red with TMRM. The cells turn yellow (red and green) before they turn green, indicating that YFP-Bax travels to the mitochondria before transmembrane potential is lost. Video courtesy of David Andrews and Tony Collins, McMaster University, Hamilton. See more confocal microscopy images in the Cell Picture Show: https://www.cell.com/pictureshow/cell-death
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