Bruchpilot Acetylation Influences Active Zone Structure
2,358 views · Published 15 November 2011 · 4:22 · Indexed 8 November 2026
Channel: Cell Press · 2011 · Science & Technology
Patrik Verstreken and co-authors find that in addition to acetylating histones in the nucleus, the histone acetyl-transferase ELP3 plays a role at the synapse where it acetylates the active zone-associated protein Bruchpilot. Lack of ELP3 leads to defects in active zone morphology and altered neurotransmitter release, which suggests that ELP3-dependent acetylation of Bruchpilot may be fundamental Video maintaining the structural integrity of presynaptic densities and supporting neurotransmitter release. For more information, see Miskiewicz et al., Neuron 72(5).
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