Natural Off-Switch of Cas9/Cell, Dec. 8, 2016 (Vol. 167, Issue 7)

1,658 views · Published 9 December 2016 · 3:37 · Indexed 31 October 2026

Channel: Cell Press · 2016 · Science & Technology

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CRISPR-Cas9 has been repurposed to precisely edit the genome. In this video and the Cell paper published in the December 15 issue of Cell, Alan Davidson's group at the University of Toronto and Erik Sontheimer's group at Umass Worcester show that there are naturally occurring phage proteins that can directly bind with Cas9 and curb its DNA targeting and cleaving activity. These exciting findings provide limitless potentials for their future applications.  Check out the paper at:  http://www.cell.com/cell/fulltext/S0092-8674(16)31589-6.

April Pawluk, Nadia Amrani, Yan Zhang, Bianca Garcia, Yurima Hidalgo-Reyes, Jooyoung Lee, Alireza Edraki, Megha Shah, Erik J. Sontheimer, Karen L. Maxwell, and Alan R. Davidson (2016). Naturally Occurring Off-Switches for CRISPR-Cas9. Cell 167.

And read more great research at http://www.cell.com/cell/home.

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