Visualizing Microtubule Bundle Formation and Quantification of the Cell Bundle Index
670 views · Published 18 November 2014 · 0:12 · Indexed 12 November 2026
Channel: Cell Press · 2014 · Science & Technology
Under the assumption of microtubule stabilization due to taxane treatment, the self-arrangement of growing microtubules into bundles has been simulated according to a range of parameters. Key intracellular physical properties that influence bundle formation include microtubule stiffness and cytoplasm viscosity. The automatic method for calculating and visualizing the bundle index, which is the number that quantifies collective proximity and orientation of the microtubules, has also been developed and compared to experimental data. See the paper by Kim and Rejniak in the November 18 issue of Biophysical Journal. Read more at http://www.cell.com/biophysj/abstract/S0006-3495(14)00725-5
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