OLMα2 Cells and Their Role in Learning

595 views · Published 24 July 2018 · 4:29 · Indexed 12 November 2026

Channel: Cell Press · 2018 · Science & Technology

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For more information, see Siwani et al., Neuron 99/2, http://www.cell.com/neuron/fulltext/S0896-6273(18)30490-2.

Siwani et al. have used optogenetics to study a subpopulation of interneurons called OLMα2 cells and show that these cells exert bidirectional modulation on learning. OLMα2 cells carry the Chrna2 subunit, respond to nicotine, and act as gatekeepers to control the flow of internal versus external information within the hippocampus.

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