Elevator-like Translocation Mechanism Proposed for a Sodium-Coupled Phosphate Transporter

458 views · Published 6 September 2016 · 0:33 · Indexed 26 October 2026

Channel: Cell Press · 2016 · Science & Technology

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During the transition between outward- and inward-facing states, the so-called transport domain (orange) is predicted to move against a scaffold-like domain (blue), shown here using a simple morph and viewed from within the plane of the membrane. Sodium (purple spheres) and phosphate (red spheres) have been placed according to electrophysiological and biochemical evidence. See the article by Patti et al. in the September 6 issue of Biophysical Journal (http://www.cell.com/biophysj/fulltext/S0006-3495(16)30594-X).

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