RhoA, Live and in Color/Cell Reports, Timpson et al., Movie S5

959 views · Published 5 October 2017 · 1:39 · Indexed 25 October 2026

Channel: Cell Press · 2017 · Science & Technology

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The small GTPase RhoA is a major signaling hub in most cells, but its actions can be difficult to track. Timpson and colleagues developed a biosensor that reveals RhoA activation in living tissues and used it to examine signaling in real time. This movie shows three prime examples.

Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, et al. (2017). A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts. Cell Reports 21.

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