Cortical Inactivation Freezes Dopamine's Sensitivity to Belief
1,020 views · Published 2 May 2018 · 6:32 · Indexed 21 October 2026
Channel: Cell Press · 2018 · Science & Technology
For more information, see Starkweather et al., Neuron 98/3, http://www.cell.com/neuron/fulltext/S0896-6273(18)30242-3. Dopamine signals, thought to drive reinforcement learning, are suppressed by reward expectation, including sensitivity to the animal's belief about whether or not a reward will be delivered. By inactivating the medial prefrontal cortex, Starkweather et al. (2018) was able to "trick" dopamine neurons into signaling as if they were no longer sensitive to the animal's beliefs.
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