Hitting on the Causes of Diabetes / Cell, June 29, 2017 (Vol. 170, Issue 1)

1,862 views · Published 29 June 2017 · 3:58 · Indexed 14 November 2026

Channel: Cell Press · 2017 · Science & Technology

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Many genetic variants have been linked with the risk of developing type 2 diabetes, but do we really understand why? Learn how Victor Rusu, Eitan Hoch,  and colleagues at the Broad Institute tackled this problem and discovered that a common genetic variant associated with diabetes causes impaired function of a cellular transporter that in turn impacts metabolic state of the cell. Check out the paper at:  http://www.cell.com/cell/fulltext/S0092-8674(17)30694-3.

V. Rusu, E. Hoch, J. M. Mercader, D. E. Tenen, M. Gymrek, C. R. Hartigan, M. DeRan, M. von Grotthuss, P. Fontanillas, A. Spooner, et al. (2017). Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell 170.  

And read more great research at http://www.cell.com/cell/home.

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