Thalamostriatal Dysfunction and Conflicted Action in Aging

532 views · Published 20 April 2016 · 7:35 · Indexed 12 November 2026

Channel: Cell Press · 2016 · Science & Technology

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For more information, see the paper by Matamales et al., Neuron 90(3), http://www.cell.com/neuron/fulltext/S0896-6273(16)00185-9.

Behavioral adaptation is essential to survive in an ever-changing environment. Here, Bertran-Gonzalez and his team show a specific deficit in thalamostriatal circuits that prevents normally aged mice from integrating new with previous learning during the adaptation of action, resulting in conflicted goal-directed behavior.

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