The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

2,737 views · Published 28 March 2013 · 5:00 · Indexed 21 October 2026

Channel: Cell Press · 2013 · Science & Technology

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Ron Germain and colleagues identify the mitochondrial adapter molecule MAVS as a critical regulator of inflammasome activation. They discuss their findings on how MAVS and another adapter, ASC, are both required for maximal NLRP3 function.

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