Ascoidea asiatica Translates CUG Codons Randomly/ Curr. Biol., Jun. 14, 2018 (Vol. 28, Issue 13)

818 views · Published 14 June 2018 · 3:21 · Indexed 12 November 2026

Channel: Cell Press · 2018 · Science & Technology

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Mühlhausen et al. discovered the first species in which the non-ambiguity rule of the genetic code is broken. Ascoidea asiatica stochastically translates CUG into both leucine and serine, as evident in high-throughput proteomics data. Comparative tRNA analysis suggests this to be caused by two competing, active tRNAs. A. asiatica seems to cope with stochastic CUG translation through using the codon rarely and never at conserved positions.

Check out the paper at http://www.cell.com/current-biology/fulltext/S0960-9822(18)30557-8.

S. Mühlhausen, H.D. Schmitt, K.-T. Pan, U. Plessmann, H. Urlaub, L.D. Hurst, and M. Kollmar (2018). Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica. Curr. Biol. 28.

And read more great research at http://www.cell.com/current-biology/home.

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