Cell Death in Intestinal Epithelial Organoids / Cell Reports, December 19, 2017 (Vol. 21, Issue 12)

1,128 views · Published 5 January 2018 · 0:10 · Indexed 29 October 2026

Channel: Cell Press · 2018 · Science & Technology

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Lamkanfi and colleagues examine the mechanisms through which the inflammasome sensors NLRP1b and NLRC4 regulate apoptosis. The video shows primary intestinal epithelial organoids undergoing pyroptosis and apoptosis. B6Nlrp1b+, B6Nlrp1b+C1−/−C11−/−, and B6Nlrp1b+C1−/−C11−/− ASC−/− organoids were stimulated with FlaTox and followed in time for 16 hr in the presence of propidium iodide. 
Check out the paper at: http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31755-2. 

Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi (2017). Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4. Cell Reports 21.

And read more great, open-access research at http://www.cell.com/cell-reports/home.

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