Midbrain Dopamine Neurons Induce Late-Stage Adaptive Behavior of Addiction

1,555 views · Published 2 December 2015 · 4:50 · Indexed 22 October 2026

Channel: Cell Press · 2015 · Science & Technology

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The majority of mice that are allowed to self-stimulate projection neurons of the VTA continue to do so even they have to endure a punishment, such as a mild electric shock. The study identifies the causal role of hyperexitability of the lateral orbit-frontal cortex in this adaptive behavior.

For more details, see the paper by Pascoli et al., Neuron 88(5), at http://www.cell.com/neuron/abstract/S0896-6273(15)00883-1.

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