Sonic Hedgehog Directs Cortical Circuit Formation

1,269 views · Published 21 March 2012 · 3:59 · Indexed 31 October 2026

Channel: Cell Press · 2012 · Science & Technology

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Sonic Hedgehog is one of the most widely studied molecules in developmental biology, with critical functions in tissue patterning, and proliferation and specification of adult neural stem and cancer cells.  Arnold Kriegstein and colleagues now identify a novel function for Sonic Hedgehog in directing synapse formation in a specific cortical circuit, which is dependent on the Sonic Hedgehog receptor Boc.

For more details see Harwell et al., Neuron 73(6).

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