Actin Cortex Dynamics

918 views · Published 24 March 2015 · 0:21 · Indexed 26 October 2026

Channel: Cell Press · 2015 · Science & Technology

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Atomic-force microscopy imaging (loading force: 150 pN) of the actin cortex dynamics in living NIH-3T3 fibroblasts. This video shows the response of the actin cortex to specific inhibition of the actin-branching complex Arp2/3 by the drug CK666. Transition of a tight meshwork of actin (mesh) to parallel arrays of actin bundles or to actin stars was induced by the addition of 50 µM CK666 to the cells. Acquisition time was 256 s/image. See the article by Eghiaian et al. in the March 24 issue of Biophysical Journal.

Read more at http://www.cell.com/biophysj/abstract/S0006-3495(15)00079-X

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